Science & Research

Our Science

Science is at the heart of everything we do. Scientific publications and clinical studies inform and drive our product development process, from concept to market access.

The safety of SKF7™ has been demonstrated by OECD- and USFDA-compliant studies:


Pre- Clinical Studies:

  • Genotoxicology – completed
  • In-vivo toxicology – completed
  • In-vivo and in-vitro efficacy studies – completed
  • Pharmacokinetic studies – completed
  • Pharmacodynamic studies – completed

Pre-clinical research shows that SKF7™ inhibits visceral fat accumulation in high-fat diet rodents and exhibited anti-obesity effects. Case studies in humans reported normalization of blood glucose levels and reduction in total cholesterol, triglyceride levels and waist circumferences.

We have also launched a multi-centre Phase 2 Dose-Ranging A Randomized Double-Blind Placebo-Controlled Study Of SKF7™ For Anti-Obesity in 11 healthcare facilities across Malaysia, Indonesia and India.

This study involves 312 subjects and is part of the process in obtaining approval for SKF7™ to be classified and marketed as a botanical drug.

Pre-clinical studies are also ongoing with SKF7™ for the treatment of diabetes mellitus, cancer, and Covid-19.

Each one of Medika Natura’s products is put through a stringent end-to-end quality control mechanism using our proprietary technology platform, PhytoProfile™, to ensure they maintain consistent safety, quality and efficacy standards.

Botanical Drugs


Cardiovascular Health



Women's Reproductive Health

Our Research

Scientific publications and clinical studies inform and drive our product development process, from concept to market access.

Download Research Papers

A country level analysis measuring the impact of government actions, country preparedness and socioeconomic factors on Covid-19 mortality and related health concerns

Authors: Rabail Chaudhry, George Dranitsaris, Talha Mubashir, Justyna Bartoszko, and Sheila Riazi / Date published: Jul 2020

OpenSAFELY: factors associated with Covid-19-related hospital death in the linked electronic health records of 17 million adult NHS patients

Authors: Elizabeth Williamson, Alex J Walker, Krishnan Bhaskaran, Seb Bacon, ChrisBates, Caroline E Morton, Helen J Curtis, Amir Mehrkar, David Evans,Peter Inglesby, Jonathan Cockburn, Helen I McDonald, Brian MacKenna, Laurie Tomlinson, Ian J Douglas, Christopher T Rentsch, Rohini Mathur, Angel Wong, Richard Grieve, David Harrison, Harriet Forbes, Anna Schultze, Richard Croker, John Parry, Frankm Hester, Sam Harper, Raf Perera, Stephen Evans, Liam Smeeth, and Ben Goldacre / Date published: May 2020

Evaluation of Safety and Efficacy of Labeesity® for Weight Management and Fatigue in an Obese Female Patient with Hypothyroidism: A Case Report

Authors: Aman Shah Abdul Majid, Elham Farsi, Natesan Vijayalakhshmi, Syarifah Aisya Syed Amran, Mahibub Mahadmadsa Kanakal, and Zarina Thasneem Zainudeen / Date published: Jun 2019

The effects of Labisia pumila var alata extracts on the lipid profile, serum antioxidant status and abdominal aorta of high-cholesterol diet rats

Authors: Roza Dianita, Ibrahim Jantan, Juriyati Jalil, and Athirah Zawani Amran / Date published: Jul 2016

Gallic Acid Regulates Body Weight and Glucose Homeostasis Through AMPK Activation

Authors: Khanh V. Doan, Chang Mann Ko, Ann W. Kinyua, Dong Joo Yang, Yun-Hee Choi, In Young Oh, Nguyen, Ara Ko, Jae Won Choi, Yangsik Jeong, Min Ho Jung, Won Gil Cho, Shanhua Xu, Kyu Sang Park, Woo Jin Park, Soo Yong Choi, Hyoi / Date published: Oct 2014

Efficacy and Safety of Labisia pumila var alata Water Extract Among Pre- and Post menopausal Women

Authors: Mohd Noor Norhayati, Annie George, Nik Hazlina Nik Hussain, Abdul Kadir Azidah, Hassan Intan Idiana, Kim Sooir Law, Ismail Shaiful Bahari, Wan Mohamed Wan Zahiruddin, Eckehard Liske, and Abas Azreena / Date published: Jul 2014

Labisia pumila Upregulates Peroxisome Proliferator-Activated Gamme Expression in Rat Adipose Tissues and 3T3-L1 Adipocytes

Authors: Fazliana Mansor, Harvest F. Gu, Claes-Goran Ostenson, Louise-Manneras-Holm, Elisabet Stener-Victorin, and Wan Nazaimoon Wan Mohamud / Date published: Jul 2013

Labisia pumila: A review on its Traditional, Phytochemical and Biological Uses

Authors: Norhanisah Abdullah, Siavash Hosseinpour Chermahini, Chua Lee Suan, and Mohammad Roji Sarmidi / Date published: Jan 2013

Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis

Authors: Siti Noor Fathilah, Shahrum Abdullah, Norazlina Mohamed, and Ahmad Nazrun Shuid / Date published: Sep 2012

The Effect of Labisia pumila var. alata on Postmenopausal Women: A Pilot Study

Authors: Azidah Abdul Kadir, Nik Hazlina Nik Hussain, Wan Mohammad Wan Bebakar, Dayang Marshitah Mohd, Wan Mohd Zahiruddin Wan Mohammad, Intan Idiana Hassan, Norlela Shukor, Nor Azmi Kamaruddin, and Wan Nazaimooon Wan Mohamud / Date published: Apr 2012

Labisia pumila extract down-regulates hydroxysteroid (11-beta) dehydrogenase 1 expression and cortiscosterone levels in ovariectomized rats

Authors: Mansor Fazliana, Harvest F. Gu, Claes-Goran Ostenson, Mashitah Mohd Yusoff, and W. M Wan Nazaimoon / Date published: Aug 2011

Labisia pumila extract regulates body weight and adipokines in ovariectomized rats

Authors: Mansor Fazliana, Wan Nazaimoon Wan Mohamud, Harvest F. Gu, and Claes-Goran Ostenson / Date published: Jan 2009

Effect of Water Extract of Labisia pumila Var Alata on Aorta of Ovariectomized Sprague Dawley Rats

Authors: Ayida Al-Wahaibi, W.M Wan Nazaimoon, W.N Norsyam, H.S. Farihah, and A.L Azian / Date published: 2008

Drugs from nature: past achievement future prospects

Authors: Gordon M Cragg and David J Newman / Date published: 2002